Oregon Esthetician State Board Exam Prep 2025 – Complete Practice Resource

The thickest skin on the human body is found on the palms of the hands and the soles of the feet. This area of skin is specialized to withstand more mechanical stress and friction, which is necessary due to the frequent use of these parts of the body for gripping and walking. The skin in these regions contains a higher concentration of the protein keratin, which provides additional protection and durability.

Conversely, the eyelids have the thinnest skin, as they require flexibility for movement. The skin on the cheeks is also comparatively thinner than that on the palms and soles, as it does not typically experience the same level of wear and tear. Similarly, the skin on the back is thick but does not compare to the thickness found on the palms and soles, primarily because the back does not undergo the same constant friction and pressure. Thus, the palms of the hands and soles of the feet are uniquely structured to protect against environmental factors and physical stress, confirming that this is where the thickest skin is located.